He signed with the Buffalo Sabres and has played with the team since 2016. Okposo has also represented the United States in international competition and won a bronze medal at the 2007 World Junior Championships. In 2017 he was selected to the NHL All-Star Game. Okposo signed a seven year deal for $42 million with the Sabres in 2016. In March 2017 he was hospitalized in a neurosurgical intensive care unit and would go onto miss the rest of the season.