RedOne moved to the United States in 2007. He worked with Kat DeLuna and remixed a song by Jennifer Lopez. He was introduced to and started working with Lady Gaga. He has produced or written for many popular artists including Britney Spears, Pitbull, Akon, Marc Anthony, Justin Bieber, Mary J Blige, Brandy, Cher, Jason Derulo, Selena Gomez, Enrique Iglesias, Lindsay Lohan, Nicki Minaj, Lionel Richie, Usher, Lil Wayne, Backstreet Boys, New Kids on the Block, One Direction, and the Ying Yang Twins. RedOne started 2101 Records in 2010 with Universal Music Group. The artists signed to the label include Jennifer Lopez, Havana Brown, Midnight Red, and 7Lions. He also created the non-profit 2101 Foundation which helps youth. Khayat was nominated for a Grammy and a Latin Grammy in 2011. At the beginning of 2016, Khayat signed a record contract with Warner Bros., going on to drop his first single a few months later in May with artists Enrique Iglesias, R. City, Serayah, and Shaggy all assisting him on the track, entitled (somewhat humorously given the number of featured artists on the song) “Don’t You Need Somebody.”